Comparable antigen-specific T cell responses in vaccinees with diverse humoral immune responses after the primary and booster BBIBP-CorV vaccinationArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] Anti-spike Antibody Response B cell B cell responses BBIBP-CorV booster booster vaccination CD4 CD8 comparable COVID-19 COVID-19 vaccines de novo demonstrated detectable dramatic increase Epidemic exhibited Features humoral immune response Humoral immunity humoral responses interferon-γ Neutralizing antibodies omicron remained S protein SARS-CoV-2 SARS-COV-2 infection serotype Severe case Shanghai significantly T cell T cell response T cell responses T cell responses. Th1 cytokine vaccination vaccinee vaccinees wild type [DOI] 10.1080/22221751.2022.2130101 PMC 바로가기
Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
Clinical course of novel COVID-19 infection in pregnant womenObservational Study Published on 2022-12-012022-10-05 Journal: The journal of maternal-fetal & neonatal medicine [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] alanine aminotransferase analyzed Anemia Anosmia antimicrobial APGAR score Asymptomatic C-reactive protein carbapenem change clinical Clinical course clinical symptom contribute coronavirus cough Course COVID-19 COVID-19 infection CPAP therapy creatinine CRP decrease demographic disease drug Elimination epidemiological erythrocyte excluded form Immunity increase in Infection interferon Laboratory lactate dehydrogenase LDH leukopenia low molecular weight lymphocyte manifestation maternal and perinatal outcomes. mechanical ventilation Mild moderate morbidity Neonatal Neonatal COVID-19 Neonate no evidence of occurred outcome outcomes Oxygenation PCR polymerase chain predictor Pregnancy pregnant women preterm delivery prospective observational study recommendations reported required SARS-CoV-2 Severe case severe COVID-19 Spontaneous Transmission virus women [DOI] 10.1080/14767058.2020.1850683 PMC 바로가기 [Article Type] Observational Study
Porcine deltacoronavirus E protein induces interleukin-8 production via NF-κB and AP-1 activationArticle Published on 2022-11-012022-11-15 Journal: Veterinary microbiology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] abrogated activated activating Activation acute respiratory syndrome Alpha antiviral immunity AP-1 binding C-terminal domain caused chemokine coronavirus coronavirus disease COVID-19 Cytokine release syndrome deleting demonstrated dependent on domain E E protein expression facilitate help IL-6 IL-8 induce Infection Inflammation inhibitor interleukin-6 IκBα life-threatening Local molecular mechanism motif NF-κB NF-κB pathway nuclear nuclear translocation p65 Pathogenesis PDCoV. Phosphorylation Proinflammatory cytokine promoter protein phosphorylation resulting SARS-CoV-2 Severe case upregulated [DOI] 10.1016/j.vetmic.2022.109553 PMC 바로가기
[Clinical features of 19 children infected with the Omicron variant of severe acute respiratory syndrome coronavirus 2 in Hangzhou, China]Article Published on 2022-10-152022-11-16 Journal: Zhongguo dang dai er ke za zhi = Chinese journal o [Category] COVID19(2023년), SARS, 변종, [키워드] abnormality accounted acute respiratory syndrome age alanine aminotransferase Aspartate aminotransferase Care Chest CT Child children Chinese clinical clinical feature close contact Cluster common clinical symptom coronavirus coronavirus disease cough COVID-19 creatinine cured diagnosed discharged English Epidemic feature Fever Infant infected with SARS-CoV-2 Infection interferon involved Liver function Lymphocyte count median age Mild Mild symptom MOST omicron Omicron variant outbreak parameter Platelet Pneumonia procalcitonin Prognosis ranged renal function SARS-CoV-2 SARS-CoV-2 vaccine Severe acute respiratory syndrome coronavirus 2 infection. Severe case strain Symptomatic treatment underlying diseases urea variant were given White blood cell [DOI] 10.7499/j.issn.1008-8830.2205122 PMC 바로가기
Limited value of neutrophil-to-lymphocyte ratio and serum creatinine as point-of-care biomarkers of disease severity and infection mortality in patients hospitalized with COVID-19Article Published on 2022-10-062022-11-15 Journal: PLoS ONE [Category] 바이오마커, [키워드] 95%CI Accuracy adjusted analyzed AOR association assumption Biomarker cohort study COVID-19 COVID-19 patient creatinine cut-off death disease severity elevated enrolled hospital hospitalized COVID-19 Infection IQR Limited males median age monitoring Mortality Neutrophil-to-lymphocyte ratio NLR non-survivor Odds ratio outcome Patient patients hospitalized point-of-care predict predictor Prognosis Prognostic marker progression Prospective receiver operating characteristics Sensitivity and specificity serum creatinine Severe case severity significantly significantly higher Still survivor the disease Treatment with COVID-19 [DOI] 10.1371/journal.pone.0275391 PMC 바로가기
Classification of lungs infected COVID-19 images based on inception-ResNetResearch article Published on 2022-10-012022-10-05 Journal: Computer methods and programs in biomedicine [Category] 진단, 치료기술, [키워드] 3D convolution Accuracy applied auxiliary backbone carried Chest classification Classifier Clinical diagnosis collected data COVID-19 COVID-19 diagnosis COVID-19 patient CT imaging CT scan dataset diagnose diagnostic disease effective Efficiency effort ENhance expected experiment greater hospital identify image classification IMPROVE Inception-ResNet lung mechanism medical diagnosis Numerous objective Patient performed Perspective Prevent processed Result Severe case severe COVID-19 patient Spread survival the disease TPR Treatment [DOI] 10.1016/j.cmpb.2022.107053 [Article Type] Research article
Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2Article Published on 2022-10-012022-11-15 Journal: Biochimie [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 Admission association Biomarker circulating Comorbidities Course COVID-19 COVID-19 patient COVID-19 patients D-dimer Diabetes Mellitus disease disease severity early phase effective ELISA healthy controls host receptor hypertension increase in Infection investigated involved marker membrane moderate outcome plasma Plasma level positive correlation sACE2 sACE2. SARS-CoV-2 Severe case shown significant increase soluble ACE2 the SARS-CoV-2 was determined was obtained was performed [DOI] 10.1016/j.biochi.2022.06.005 PMC 바로가기
Serum biomarkers associated with SARS-CoV-2 severityArticle Published on 2022-09-262022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, [키워드] acute phase Angiogenesis Asymptomatic biological marker Biomarker cardiovascular diseases chemokine Clinical course controls correlated cytokine D-dimer disease disease severity elevated evaluated Factor group groups Growth factors help Hospitalized identify immune response individual infected with SARS-CoV-2 Infection Mild negative control Patient patients with SARS-CoV-2 prognostic Prognostic markers RT-PCR SARS-CoV-2 SARS-COV-2 infection sera Severe case severity [DOI] 10.1038/s41598-022-20062-5 PMC 바로가기
Low SARS-CoV-2 viral load among vaccinated individuals infected with Delta B.1.617.2 and Omicron BA.1.1.529 but not with Omicron BA.1.1 and BA.2 variantsArticle Published on 2022-09-202022-11-16 Journal: Frontiers in Public Health [Category] SARS, 변종, [키워드] Analysis analysis Asymptomatic disease AZD1222 B.1.1.529 B.1.617.2 BBV152 Case-control Chennai Clinical characteristics clinical history Clustering Complete COVID-19 COVID-19 diagnosis COVID-19 severity Delta demographic characteristics disease Disease progression epidemiological Hospitalized Immune escape India individual Ion Lineage Mutation next generation sequencing number of comorbidities omicron Omicron BA.2 performed Phylogenetic analysis Phylogeny phylogeny. predict Randomly reported RT-PCR SARS-CoV-2 variant SARS-CoV-2 viral load selected selective sequence Severe case severe disease Spread strain System TaqPath unique vaccinated individual vaccine dose variant variants variants of SARS-CoV-2 virological marker virus strains was performed WGS [DOI] 10.3389/fpubh.2022.1018399 PMC 바로가기